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    Liver transplant recipients with HCV fare well under drug combo

    For post-liver transplant recipients infected with hepatitis C virus (HCV), a combination of ledipasvir and sofosbuvir without ribavirin yields excellent outcomes and favorable safety and tolerability profiles, according to a new study.

    Current guidelines recommend including ribavirin when treating post-transplant patients because of a lack of efficacy data of therapies without ribavirin.

    “This study, the largest single-center experience of post-liver transplant patients with HCV genotype 1 recurrence taking direct-acting antivirals (DAAs) without ribavirin, is uniquely designed to determine the effectiveness of DAAs in post-transplant patients without ribavirin,” Joel Wedd MD, MPH, assistant professor of medicine and director of the Liver Tumor Clinic at Atlanta-based Emory University Hepatology and Liver Transplantation, told Medical Economics.

    This is particularly important because ribavirin has side effects, especially in the post-transplant population, he noted.

    The researchers published their in the June 2017 Alimentary Pharmacology & Therapeutics.

    Next: Study details

    Mark L. Fuerst
    Staff Correspondent


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